Pre-Grant Publication Number: 20100273800
Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
Filing Date: September 22, 2008Priority Date: August 25, 2006
Inventors: Steven Magnuson, Philip Wickens, Zhonghua Zhang, Ning Qi, Xin Ma
Assignee(s): Bayer Healthcare
Current U.S. Classification: 514, 514/243000, 544, 544/183000
View Prior Art for Claim 00001
A compound having be formula (I):or a physiologically acceptable salt or stereoisomer thereof, wherein:R1 is —(C1-C4)alkyl, —(C1-C4)alkyl-CF3, —(C3-C6)cycloalkyl, or —(C2-C4)alkyl-NR5R6;R2 is hydrogen or —(C1-C4)alkyl;R3 is halogen;R4 is —(C1-C4)alkyl, optionally substituted with one or more hydroxy, amino, alkoxy, or cycloalkyl groups; andR5 and R6, may be the same or different, and are independently hydrogen, methyl, ethyl, or R5 and R6 may be taken together with the nitrogen to which they are bound to form a pyrrolidine ring.
#646Pyrrolotriazine Derivatives Useful For Treating Hyper-Proliferative Disorders And Diseases Associated With Angiogenesis
Applies to Claims 1,18,19
Submitted by: Lankeswararao mattiLast updated: over 2 years ago
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Description
pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
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#647Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis
Applies to Claims 1,15,16,19
Submitted by: Lankeswararao mattiLast updated: over 2 years ago
Title Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders an
Description
novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
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#648Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis
Applies to Claims 1,15,16,19
Submitted by: Lankeswararao mattiLast updated: over 2 years ago
Title Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders an
Description
novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
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